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Inflammation Support
KPV
A20-1210 · Recovery & Repair
What labs study it for
Inflammation research. Labs use this tiny three-amino-acid peptide to study inflammatory signalling in cultured cells and in models of the gut lining and skin.
What this compound is
KPV is a peptide of just three amino acids: lysine, proline and valine. The sequence is the tail end (residues 11-13) of alpha-melanocyte-stimulating hormone, a signalling molecule involved in pigmentation and inflammatory regulation. Because it is the smallest active fragment, laboratories use it as a probe for melanocortin-related inflammatory signalling in cultured cells and in animal models of mucosal inflammation, without the pigmentation activity of the full hormone. It is not approved for any medical use.
KPV. Supplied lyophilized. Lot-specific HPLC and MS documentation accompanies each unit.
3D structure
Carbon in orange, nitrogen blue, oxygen red, sulfur yellow. Formula C16H30N4O4.
Structure from PubChem CID 125672.
Sequence
- 1KLys
- 2PPro
- 3VVal
Family
All families →Melanocortin fragments
The smallest working piece of a pigment-and-inflammation hormone.
Alpha-melanocyte-stimulating hormone is a 13-residue hormone involved in pigmentation and in inflammatory regulation. Its final three residues — lysine, proline, valine — retain activity in inflammatory signalling assays without the pigmentation activity of the whole hormone. That separation is exactly why the fragment is useful in the laboratory: it isolates one arm of the hormone's behaviour.
Fields of study
- Melanocortin signalling
- Inflammatory pathway models
- Mucosal biology
Specifications
| Catalog number | A20-1210 |
|---|---|
| CAS number | 67727-97-3 |
| Molecular formula | C16H30N4O4 |
| Molecular weight | 342.43 g/mol |
| Purity (HPLC) | ≥ 99.0 % |
| Physical form | Lyophilized powder |
| Storage | -20 C, desiccated, protected from light |
| PubChem record | CID 125672 |
Literature
Published sources, listed for reference. Follow the citation for findings.
- Dalmasso G, et al. PepT1-mediated tripeptide KPV uptake reduces intestinal inflammation. Gastroenterology. 2008;134(1):166-78. PMID 18061177
Reference information for laboratory research only — not for human or veterinary use.