IGF-1 LR3

A20-5050 · Muscle Growth & Performance

What labs study it for

Cell-growth research. Labs add it to cell cultures to support cell growth in the dish, and use it to study IGF-1 receptor signalling.

What this compound is

IGF-1 LR3 is an engineered analogue of insulin-like growth factor 1, a naturally occurring protein of 70 amino acids. The analogue carries a 13-residue extension at one end and a single substitution at position 3, changes that sharply reduce its binding to IGF-binding proteins. Laboratories use it as a cell-culture supplement and as a tool for studying IGF-1 receptor signalling with reduced binding-protein interference. It is not approved for any medical use.

IGF-1 LR3. Supplied lyophilized. Lot-specific HPLC and MS documentation accompanies each unit.

Family

All families →

The IGF axis

What growth hormone actually acts through, one step later.

Growth hormone does much of its work indirectly: it prompts the liver to produce insulin-like growth factor 1, a 70-amino-acid protein that carries the signal onward. In the body IGF-1 is held in check by binding proteins that switch it off. IGF-1 LR3 is an engineered version with a 13-residue extension and one substitution at position 3, changes that sharply reduce that binding. It sits downstream of the GHRH-analogue and ghrelin-receptor families rather than alongside them.

Fields of study

IGF-1 receptor signalling
Cell culture supplementation

Specifications

Catalog number	A20-5050
CAS number	946870-92-4
Molecular formula	C400H625N111O115S9
Molecular weight	9117.60 g/mol
Purity (HPLC)	≥ 99.0 %
Physical form	Lyophilized powder
Storage	-20 C, desiccated, protected from light

Reference information for laboratory research only — not for human or veterinary use.