MOTS-c

A20-1264 · Weight Management & Metabolic · Energy & Cellular & Longevity

What labs study it for

Mitochondria and cell-energy research. Labs use it to study how mitochondria, the cell's power plants, send signals to the rest of the cell, including the AMPK energy-sensing pathway.

What this compound is

MOTS-c is a peptide of sixteen amino acids, unusual in its origin: it is encoded not by the cell nucleus but by mitochondrial DNA, within the 12S ribosomal RNA gene. Peptides of this kind are called mitochondrial-derived peptides, and MOTS-c was among the first identified. Laboratory research examines its role in AMPK signalling and folate-methionine metabolism, and its behaviour as a signalling molecule between mitochondria and the rest of the cell, principally in cell culture and rodent models.

MOTS-c. Supplied lyophilized. Lot-specific HPLC and MS documentation accompanies each unit.

3D structure

Carbon in orange, nitrogen blue, oxygen red, sulfur yellow. Formula C101H152N28O22S2.

Computed 3D model, not a measured structure. Drag to rotate · scroll to zoom.

Structure from PubChem CID 146675088, with 3D coordinates computed from it.

Family

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Mitochondrial-derived peptides

Coded by the mitochondria's own DNA, not the cell nucleus.

Almost every protein in a cell is coded by nuclear DNA. Mitochondria carry a small separate genome, and a handful of short peptides are encoded within it — a class only identified in the last two decades. MOTS-c, sixteen residues coded inside the 12S ribosomal RNA gene, was among the first. It is studied as a signalling molecule between the mitochondria and the rest of the cell.

Fields of study

Mitochondrial signalling
AMPK pathway
Metabolic regulation models

Specifications

Catalog number	A20-1264
CAS number	1627580-64-6
Molecular formula	C101H152N28O22S2
Molecular weight	2174.60 g/mol
Purity (HPLC)	≥ 99.0 %
Physical form	Lyophilized powder
Storage	-20 C, desiccated, protected from light
PubChem record	CID 146675088

Literature

Published sources, listed for reference. Follow the citation for findings.

Lee C, et al. The mitochondrial-derived peptide MOTS-c promotes metabolic homeostasis and reduces obesity and insulin resistance. Cell Metab. 2015;21(3):443-54. PMID 25738459

Reference information for laboratory research only — not for human or veterinary use.